Lipoatrophic diabetes in Irs1-/-/Irs3-/- double knockout mice
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چکیده
منابع مشابه
Lingual deficits in neurotrophin double knockout mice.
Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae. BDNF null-mutated mice exhibit specific impairments related to innervation and development of the gustatory system while NT-3 null mice have deficits in their lingual somatosensory innervation. To further evaluate the functional...
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The female patient initially showed the acquired type of total lipoatrophy at about 8 years of age. At 12 years of age, the onset of diabetes mellitus was speculated from advanced pyodermia and dedentition. At 29 years of age, glucosuria was found, and she developed proteinuria, ascites, and pretibial edema. The physical examination revealed: hepatosplenomegaly, complete absence of subcutanous ...
متن کاملHypothesis: hypothalamic dysfunction and lipoatrophic diabetes.
The concept that the hypothalamus controls anterior pituitary function via the production of neurohormonal releasing and inhibitory factors (RFs and IFs, respectively) is well documented (1). There is a growing body of evidence relating endocrine disorders to hypothalamic dysfunction that has resulted in a wide variety of endocrine and metabolic imbalances (2, 3). In an effort to explain the pa...
متن کاملPrenatal lens development in connexin43 and connexin50 double knockout mice.
PURPOSE To determine the roles of intercellular communication in embryonic eye growth and development, mice with a targeted deletion of the Cx43 gene were examined, and mice without both Cx43 and Cx50 were generated and analyzed. METHODS Embryonic eyes and lenses from wild-type mice, or mice deficient in Cx43, Cx50, or both Cx43 and Cx50 were collected and analyzed structurally by light and e...
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ORP4L, a member of the Oxysterol-binding protein (OSBP) related-proteins (ORPs) family, has been shown crucial in cell survival. But its role in macrophage function and effect in atherosclerosis are not clear. The mouse lack of ApoE spontaneously develops atherosclerosis lesions on a high-fat diet, and the distribution of the atherosclerosis plaques is similar to human. Thus ApoE knockout mouse...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2002
ISSN: 0890-9369
DOI: 10.1101/gad.1034802